Gablofen® Concentration Calculator

Select pump size, input your patient's intrathecal baclofen dosage, select pump reserve amount, and click Calculate.

Refer to pump manual and follow specific instructions and precautions for programming the pump and/or refilling the reservoir.

This tool is intended to help healthcare providers determine the proper concentration of Gablofen (baclofen injection) for monotherapy use with an intrathecal pump. By using this calculator, you acknowledge that the calculated doses do not account for patient variability and are not a substitute for your own clinical knowledge, experience, and judgment.

Results based on today's date: .

Choose Pump Size

Enter Patient Dosage

Select Pump Reserve Amount (mL)

Days* of drug supply (by concentration for 40 mL pump)

500 mcg/mL

100

Refill by
03/23/2015

Approved for only up to 180 days
1,000 mcg/mL

120

Refill by
04/07/2017

Approved for only up to 180 days
2,000 mcg/mL

150

Refill by
05/20/2018

Approved for only up to 180 days
Number of days until 1 mL of drug remains in pump. Refill pump before drug supply decreases below 1 mL.
Gablofen is approved for only up to 180 days of use in the Medtronic SynchroMed® Programmable Pump or other pumps labeled for intrathecal administration of Gablofen. At this selected dose and concentration, there will be additional Gablofen remaining in the pump reservoir at 180 days.

This calculator is also available for your iPad®.

iPad is a registered trademark of Apple Inc.

Indications and Usage

IMPORTANT RISK INFORMATION

WARNING: DO NOT DISCONTINUE ABRUPTLY

See full prescribing information for complete boxed warning

Abrupt discontinuation of intrathecal baclofen, regardless of the cause, has resulted in sequelae that include high fever, altered mental status, exaggerated rebound spasticity, and muscle rigidity, that in rare cases has advanced to rhabdomyolysis, multiple organ-system failure and death.

Prevention of abrupt discontinuation of intrathecal baclofen requires careful attention to programming and monitoring of the infusion system, refill scheduling and procedures, and pump alarms. Patients and caregivers should be advised of the importance of keeping scheduled refill visits and should be educated on the early symptoms of baclofen withdrawal. Special attention should be given to patients at apparent risk (e.g. spinal cord injuries at T-6 or above, communication difficulties, history of withdrawal symptoms from oral or intrathecal baclofen). Consult the technical manual of the implantable infusion system for additional post-implant clinician and patient information.

CONTRAINDICATIONS

WARNINGS AND PRECAUTIONS

ADVERSE REACTIONS

USE IN SPECIFIC POPULATIONS